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1994-08-09
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Document 0053
DOCN M9480053
TI Ability of HIV to promote a TH1 to TH0 shift and to replicate
preferentially in TH2 and TH0 cells [see comments]
DT 9410
AU Maggi E; Mazzetti M; Ravina A; Annunziato F; de Carli M; Piccinni MP;
Manetti R; Carbonari M; Pesce AM; del Prete G; et al; Division of
Clinical Immunology and Allergy, University of; Florence, Italy.
SO Science. 1994 Jul 8;265(5169):244-8. Unique Identifier : AIDSLINE
MED/94294788
CM Comment in: Science 1994 Jul 8;265(5169):193-4
AB Both interferon gamma (IFN-gamma) produced by T helper 1 (TH1)
lymphocytes and interleukin-4 (IL-4) produced by TH2 lymphocytes were
reduced in either bulk circulating mononuclear cells or mitogen-induced
CD4+ T cell clones from the peripheral blood of individuals infected
with human immunodeficiency virus (HIV). There was a preferential
reduction in clones producing IL-4 and IL-5 in the advanced phases of
infection. However, enhanced proportions of CD4+ T cell clones producing
both TH1-type and TH2-type cytokines (TH0 clones) were generated from
either skin-infiltrating T cells that had been activated in vivo or
peripheral blood T cells stimulated by antigen in vitro when cells were
isolated from HIV-infected individuals. All TH2 and most TH0 clones
supported viral replication, although viral replication was not detected
in any of the TH1 clones infected in vitro with HIV. These results
suggest that HIV (i) does not induce a definite TH1 to TH2 switch, but
can favor a shift to the TH0 phenotype in response to recall antigens,
and (ii) preferentially replicates in CD4+ T cells producing TH2-type
cytokines (TH2 and TH0).
DE Acquired Immunodeficiency Syndrome/IMMUNOLOGY Cell Line Cells,
Cultured Human HIV/*PHYSIOLOGY HIV
Infections/*IMMUNOLOGY/MICROBIOLOGY HIV Seropositivity/IMMUNOLOGY
Immunologic Memory Interferon Type II/*BIOSYNTHESIS
Interleukin-4/BIOSYNTHESIS Interleukin-5/BIOSYNTHESIS
Interleukins/*BIOSYNTHESIS Lymphocyte Transformation Phenotype
Support, Non-U.S. Gov't T-Lymphocytes,
Helper-Inducer/*IMMUNOLOGY/MICROBIOLOGY Virus Replication JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).